Elenbaas R M, Mattson K, Cole H, Steele M, Ryan J, Robinson W
Ann Emerg Med. 1984 Nov;13(11):994-9. doi: 10.1016/s0196-0644(84)80057-8.
We undertook a study to determine the ability of intravenous bretylium to cause "chemical defibrillation" or facilitate electrical defibrillation of hypothermia-induced ventricular fibrillation in the dog. Two groups of ten dogs were cooled to 22 C and placed into ventricular fibrillation. Following initiation of cardiopulmonary resuscitation, bretylium 15 mg/kg or normal saline was administered and the dogs were defibrillated according to a standard protocol. Both groups were equivalent in mean arterial pressure and arterial blood gases throughout the investigation. Seven dogs in each group were converted from ventricular fibrillation to an organized cardiac rhythm (P greater than .05). Despite the possible value of prophylactic bretylium in the setting of hypothermia, its use as active treatment for hypothermia-induced ventricular fibrillation in dogs does not seem to be beneficial.
我们进行了一项研究，以确定静脉注射溴苄铵能否引起“化学除颤”或促进犬低温诱导的心室颤动的电除颤。两组各十只犬被冷却至22℃并诱发心室颤动。在开始心肺复苏后，给予15mg/kg溴苄铵或生理盐水，并根据标准方案对犬进行除颤。在整个研究过程中，两组的平均动脉压和动脉血气均相当。每组七只犬从心室颤动转为有组织的心律（P>0.05）。尽管预防性使用溴苄铵在低温情况下可能有价值，但将其用作犬低温诱导的心室颤动的积极治疗方法似乎并无益处。
