Kosharskaia I L, Makarychev V A, Ul'ianinskií L S
Fiziol Zh SSSR Im I M Sechenova. 1978 Mar;64(3):285-91.
Effects of neorpinephrine, epinephrine, and acetylcholine 4.5.10(-7) M--2.9.10(-6)M on the automatic activity of the pace-maker cells of the rabbit atrioventricular valves were studied. The sympathetic mediators accelerated spontaneous beating by increasing the rate of slow diastolic depolarization or by the inducing additional subthreshold potentials converted in action potentials. Acetylcholine (1.1.10(-6)M) reduced the rate of the spontaneous beating and in concentrations 2.7.10(-6)M eliminated automatic activity either by suppression of AP when subthreshold potentials gradually disappeared or by gradual decrement of AP rate and amplitude. Simultaneous application of equal doses of acetylcholine and sympathetic mediators revealed a predominant effect of acetylcholine as well as intensification of the acetylcholine effect under the influence of sympathetic mediators. Sympathetic-parasympathetic interactions can be explained by their influence on permeability of membrane of the pace-maker cells through the slow Na-Ca channel.
研究了去甲肾上腺素、肾上腺素和乙酰胆碱（浓度为4.5×10⁻⁷M - 2.9×10⁻⁶M）对兔房室瓣起搏细胞自动活动的影响。交感神经介质通过增加缓慢舒张期去极化速率或诱导额外的阈下电位转化为动作电位来加速自发搏动。乙酰胆碱（1.1×10⁻⁶M）降低了自发搏动的速率，在浓度为2.7×10⁻⁶M时，通过在阈下电位逐渐消失时抑制动作电位或通过动作电位速率和幅度的逐渐降低来消除自动活动。同时应用等量的乙酰胆碱和交感神经介质显示出乙酰胆碱的主要作用以及在交感神经介质影响下乙酰胆碱作用的增强。交感 - 副交感相互作用可以通过它们对起搏细胞膜通过慢钠 - 钙通道的通透性的影响来解释。
