Takács L, Bencsáth P, Szalay L
Fiziol Zh SSSR Im I M Sechenova. 1978 Mar;64(3):323-34.
The denervation diuresis and natri uresiswere manifest in anesthetized dog and rats after acute or chronic renal sympathectomy with no changes in RBF, GFR or in their intrarenal distribution. Micropuncture showed the principal site of action of renal denervation on to be within the proximal tubule. The unchanged relationship between reabsorbed sodium and consumed oxygen suggested that active transport of Na decreased on denervation. No causal relationship between denervation natri uresis and decreased release of renin was revealed. As tubular transport of d-glucose, inorganic phosphate, para--aminohippurate and of uric acid was suppressed by the sympathectomy, the renal sympathetic activity seem to be able to regulate the proximal tubular transport functions.
急性或慢性肾交感神经切除术后，麻醉犬和大鼠出现去神经利尿和利钠，肾血流量、肾小球滤过率及其肾内分布无变化。微穿刺显示肾去神经支配的主要作用部位在近端小管。重吸收钠与消耗氧之间的关系未变，提示去神经后钠的主动转运减少。未发现去神经利钠与肾素释放减少之间存在因果关系。由于交感神经切除术抑制了d-葡萄糖、无机磷酸盐、对氨基马尿酸和尿酸的肾小管转运，肾交感神经活动似乎能够调节近端小管的转运功能。
