Totrova E A, Pronina N N
Fiziol Zh SSSR Im I M Sechenova. 1978 Mar;64(3):398-404.
Removal of the thyroid gland in puppies in the early postnatal period (10--20 days) suppressed the hemodynamics and the glomerular filtration, increased concentration of urine in the tubules of the kidney and reduced spontaneous diuresis. Two months after the operation, a progressive disturbance of the osmotic concentration of urine occurred, and the diuresis increased. Thyroidectomized puppies at different age are unable to react to water deprivation, to develop osmotic diuresis; the elimination of water load is lesioned. In the first 6 months the introduced water is retained in the organism. The thyroid hormones are essential for the water elimination and concentrating functions of the kidney, for its adequate hemodynamics.
在幼犬出生后的早期(10 - 20天)切除甲状腺,会抑制血液动力学和肾小球滤过,增加肾小管中尿液的浓度,并减少自发性利尿。手术后两个月,尿液的渗透浓度出现进行性紊乱,且利尿增加。不同年龄的甲状腺切除幼犬无法对缺水做出反应,无法产生渗透性利尿;水负荷的消除受到损害。在最初的6个月里,摄入的水分保留在体内。甲状腺激素对于肾脏的排水和浓缩功能及其充足的血液动力学至关重要。