Svinogeeva T P, Berezina E K, Raĭko L I
Antibiotiki. 1984 Jul;29(7):516-9.
The effect of reumycin, an antitumor antibiotic on the peripheral circulatory system and bone marrow was studied on albino rats. The drug was injected intraperitoneally in a dose of 25 mg/kg daily for 30 days. It was shown that reumycin had a comparatively low toxic effect on the peripheral circulatory system and hemopoiesis. It induced the signs of transitory anemia and did not suppress the regenerative capacity of the bone marrow. After the drug repeated use there was an increase in the platelet count and in the rate of blood coagulation. These signs vanished a month after the end of the treatment course.
研究了抗肿瘤抗生素鲁霉素对白化大鼠外周循环系统和骨髓的作用。以每日25毫克/千克的剂量腹腔注射该药物，持续30天。结果表明，鲁霉素对外周循环系统和造血功能的毒性作用相对较低。它引起了短暂贫血的症状，但并未抑制骨髓的再生能力。重复使用该药物后，血小板计数和血液凝固速率有所增加。这些症状在治疗疗程结束后一个月消失。
