L-环丝氨酸及其他抑制剂对细菌和微粒体3-酮二氢鞘氨醇合成酶的抑制作用比较
Comparative inhibition of bacterial and microsomal 3-ketodihydrosphingosine synthetases by L-cycloserine and other inhibitors.
作者信息
Sundaram K S, Lev M
出版信息
Antimicrob Agents Chemother. 1984 Aug;26(2):211-3. doi: 10.1128/AAC.26.2.211.
Abstract
Eleven compounds were examined for their capacity to inhibit the first enzyme of the sphingolipid pathway, 3-ketodihydrosphingosine synthetase. Of these, L-cycloserine was the most potent, affecting both bacterial and brain microsomal enzymes to a significant degree at 0.04 mM. D- and L-cycloserine irreversibly inactivated the enzyme, indicating a suicide substrate mode of action. L-Cycloserine was a more potent inhibitor of the growth of Bacteroides levii than was D-cycloserine, indicating that inhibition of sphingolipid synthesis could be a factor in the growth inhibition.
摘要
检测了11种化合物抑制鞘脂途径第一种酶——3-酮二氢鞘氨醇合成酶的能力。其中，L-环丝氨酸活性最强，在0.04 mM时对细菌和脑微粒体酶均有显著影响。D-环丝氨酸和L-环丝氨酸均可使该酶不可逆失活，表明其作用模式为自杀底物模式。L-环丝氨酸对产黑色素拟杆菌生长的抑制作用比D-环丝氨酸更强，这表明抑制鞘脂合成可能是抑制生长的一个因素。
相似文献
1
Comparative inhibition of bacterial and microsomal 3-ketodihydrosphingosine synthetases by L-cycloserine and other inhibitors.L-环丝氨酸及其他抑制剂对细菌和微粒体3-酮二氢鞘氨醇合成酶的抑制作用比较
Antimicrob Agents Chemother. 1984 Aug;26(2):211-3. doi: 10.1128/AAC.26.2.211.
2
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo.环丝氨酸在体外和体内对鞘脂合成的抑制作用。
J Neurochem. 1984 Feb;42(2):577-81. doi: 10.1111/j.1471-4159.1984.tb02716.x.
3
L-cycloserine inhibition of sphingolipid synthesis in the anaerobic bacterium Bacteroides levii.L-环丝氨酸对厌氧细菌脆弱拟杆菌中鞘脂合成的抑制作用。
Biochem Biophys Res Commun. 1984 Mar 15;119(2):814-9. doi: 10.1016/s0006-291x(84)80323-x.
4
Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine.L-环丝氨酸处理的小鼠大脑中脑苷脂合成的抑制作用。
J Lipid Res. 1985 Apr;26(4):473-7.
5
Dihydrosphingosine growth inhibition and repression of 3-ketodihydrosphingosine synthetase activity in Bacteroides melaninogenicus.二氢鞘氨醇对产黑色素拟杆菌的生长抑制及3-酮二氢鞘氨醇合成酶活性的抑制作用
Biochem Biophys Res Commun. 1978 Jul 14;83(1):36-42. doi: 10.1016/0006-291x(78)90394-7.
6
The 3-ketodihydrosphingosine synthetase of Bacteroides melaninogenicus: partial purification and properties.产黑素拟杆菌的3-酮二氢鞘氨醇合成酶：部分纯化及性质
Arch Biochem Biophys. 1981 Dec;212(2):424-31. doi: 10.1016/0003-9861(81)90384-2.
7
Substrate reduction intervention by L-cycloserine in twitcher mice (globoid cell leukodystrophy) on a B6;CAST/Ei background.在B6;CAST/Ei背景下，L-环丝氨酸对震颤小鼠（球状细胞脑白质营养不良）进行底物还原干预。
Neurosci Lett. 2003 Aug 14;347(1):33-6. doi: 10.1016/s0304-3940(03)00633-5.
8
The 3-ketodihydrosphingosine synthetase of Bacteroides melaninogenicus: induction by vitamin K.产黑素拟杆菌的3-酮二氢鞘氨醇合成酶：维生素K诱导作用
Arch Biochem Biophys. 1973 Aug;157(2):500-8. doi: 10.1016/0003-9861(73)90668-1.
9
Gaucher's disease.戈谢病
N Engl J Med. 1987 Aug 27;317(9):572. doi: 10.1056/NEJM198708273170913.
10
Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine.d-和l-环丝氨酸对结核分枝杆菌支链氨基酸转氨酶的基于机制的抑制作用。
ACS Chem Biol. 2017 May 19;12(5):1235-1244. doi: 10.1021/acschembio.7b00142. Epub 2017 Mar 16.
引用本文的文献
1
Preclinical studies in Krabbe disease: A model for the investigation of novel combination therapies for lysosomal storage diseases.Krabbe 病的临床前研究：用于研究溶酶体贮积病新型联合疗法的模型。
Mol Ther. 2023 Jan 4;31(1):7-23. doi: 10.1016/j.ymthe.2022.09.017. Epub 2022 Oct 4.
2
Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation.环丝氨酸对磷酸吡哆醛依赖性酶丝氨酸棕榈酰转移酶的抑制作用：一种新型脱羧失活机制的证据。
Mol Biosyst. 2010 Sep;6(9):1682-93. doi: 10.1039/c003743e. Epub 2010 May 5.
本文引用的文献
1
NEUROCHEMICAL STUDIES WITH L-CYCLOSERINE, A CENTRAL DEPRESSANT AGENT.使用中枢抑制药L-环丝氨酸的神经化学研究。
J Neurochem. 1963 Dec;10:831-9. doi: 10.1111/j.1471-4159.1963.tb11908.x.
2
LIPID COMPOSITION AND SYNTHESIS IN THE PLEUROPNEUMONIA-LIKE ORGANISM MYCOPLASMA GALLISEPTICUM.鸡败血支原体中类胸膜肺炎微生物的脂质组成与合成
J Bacteriol. 1963 Sep;86(3):370-9. doi: 10.1128/jb.86.3.370-379.1963.
3
L-cycloserine inhibition of sphingolipid synthesis in the anaerobic bacterium Bacteroides levii.L-环丝氨酸对厌氧细菌脆弱拟杆菌中鞘脂合成的抑制作用。
Biochem Biophys Res Commun. 1984 Mar 15;119(2):814-9. doi: 10.1016/s0006-291x(84)80323-x.
4
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo.环丝氨酸在体外和体内对鞘脂合成的抑制作用。
J Neurochem. 1984 Feb;42(2):577-81. doi: 10.1111/j.1471-4159.1984.tb02716.x.
5
6
The 3-ketodihydrosphingosine synthetase of Bacteroides melaninogenicus: partial purification and properties.产黑素拟杆菌的3-酮二氢鞘氨醇合成酶：部分纯化及性质
Arch Biochem Biophys. 1981 Dec;212(2):424-31. doi: 10.1016/0003-9861(81)90384-2.
7
Specificity in ceramide biosynthesis from long chain bases and various fatty acyl coenzyme A's by brain microsomes.脑微粒体利用长链碱基和各种脂肪酰辅酶A进行神经酰胺生物合成的特异性。
J Biol Chem. 1970 Jan 25;245(2):342-50.
8
Lipids of Bacteroides melaninogenicus.产黑素拟杆菌的脂质
J Bacteriol. 1970 Jan;101(1):84-91. doi: 10.1128/jb.101.1.84-91.1970.
9
The 3-ketodihydrosphingosine synthetase of Bacteroides melaninogenicus: induction by vitamin K.产黑素拟杆菌的3-酮二氢鞘氨醇合成酶：维生素K诱导作用
Arch Biochem Biophys. 1973 Aug;157(2):500-8. doi: 10.1016/0003-9861(73)90668-1.
10
Biosynthesis of sphingolipid bases. IV. The biosynthetic origin of sphingosine in Hansenula ciferri.鞘脂碱基的生物合成。IV. 西弗瑞汉逊酵母中鞘氨醇的生物合成起源。
Arch Biochem Biophys. 1971 Apr;143(2):553-65. doi: 10.1016/0003-9861(71)90240-2.
Zotero 插件