Blanco-Garcia M, Evain-Brion D, Toublanc J E, Job J C
Arch Fr Pediatr. 1984 Jun-Jul;41(6):377-80.
In its strict meaning, primary amenorrhea is defined as the absence of any menstruation in a young girl without genital malformations who has reached her complete morphological development. Twenty-four cases corresponding to this definition, with bone ages of at least 15 years, breasts for at least 2 years, and adult type pubic hair were examined. In only 10 could a cause be found: anorexia nervosa, slight hyperandrogenism, acquired intracranial lesion. The other 14 girls, mean age of 16.2 +/- 1.4 years, were considered as presenting with simple delayed menarche. They were not given treatment, although 4 of them had been given steroids in artificial cyclical form previously. The 8 who were followed finally spontaneously developed normal cycles at a mean age of 17.6 +/- 2.8 years, one not until 24 years. Such data should lead to avoiding unnecessary treatments.
严格意义上讲，原发性闭经的定义是：身体已完全发育成熟、无生殖器畸形的年轻女孩从未有过月经初潮。对符合该定义的24例病例进行了检查，这些女孩骨龄至少15岁，乳房发育至少2年，且阴毛呈成人型。其中只有10例能找到病因：神经性厌食症、轻度雄激素过多症、后天性颅内病变。另外14名女孩，平均年龄为16.2±1.4岁，被认为是单纯月经初潮延迟。她们未接受治疗，尽管其中4人之前曾接受过人工周期形式的类固醇治疗。接受随访的8名女孩最终在平均年龄17.6±2.8岁时自然建立了正常月经周期，其中1人直到24岁才建立。这些数据应能避免不必要的治疗。
