Swenne Ingemar
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Horm Res. 2008;69(3):146-51. doi: 10.1159/000112587. Epub 2008 Jan 8.
BACKGROUND/AIM: To investigate weight and growth requirements for menarche in girls with eating disorders (ED), weight loss and primary amenorrhea.
Growth charts from school health services and measurements of weight and stature throughout treatment were obtained for 47 such girls.
Weight loss started at an age of 12.4 +/- 1.6 years from a top weight of 41.7 +/- 7.1 kg. Approximately a year later they had lost 5.1 +/- 4.3 kg and grown only 2.8 +/- 3.5 cm. Following treatment and weight gain, growth accelerated and the girls reached a peak growth velocity of 4.3 +/- 2.6 cm/year 2 years before menarche which occurred at an age of 15.5 +/- 1.6 years at a weight of 52.2 +/- 5.3 kg. Menarche occurred within a wide range of weights but could be predicted by a linear regression on prepubertal weight (R(2) = 0.39; p < 0.001).
Following treatment, girls with ED and primary amenorrhea progress through puberty at a slowed rate. The weight required for menarche can be predicted by the prepubertal weight which may represent the individual's normal growth track unaffected by the ED.
背景/目的：研究饮食失调（ED）、体重减轻和原发性闭经女孩月经初潮时的体重及生长需求。
获取了47名此类女孩的学校健康服务生长图表以及整个治疗过程中的体重和身高测量数据。
体重减轻始于12.4±1.6岁，最高体重为41.7±7.1千克。大约一年后，她们体重减轻了5.1±4.3千克，身高仅增长了2.8±3.5厘米。经过治疗体重增加后，生长加速，女孩们在月经初潮前2年达到了4.3±2.6厘米/年的峰值生长速度，月经初潮发生在15.5±1.6岁，体重为52.2±5.3千克。月经初潮发生时的体重范围较广，但可通过青春期前体重的线性回归预测（R² = 0.39；p < 0.001）。
经过治疗，患有ED和原发性闭经的女孩青春期发育速度减缓。月经初潮所需的体重可通过青春期前体重预测，这可能代表了个体不受ED影响的正常生长轨迹。
