Cohen L, Morgan J, Babbs R, Karrison T G, Giacomoni M
Arch Phys Med Rehabil. 1984 Oct;65(10):573-8.
Fast walking velocity was measured in 335 apparently healthy subjects, 180 males and 155 females, whose ages ranged from 3.5 to 24 years. These velocities increased with age and approached an asymptote of 3.44m/sec in males and 3.17 m/sec in females, a statistically significant difference (p less than 0.001). This parameter was also measured serially over periods of 18 to 132 months in 15 patients with Duchenne muscular dystrophy. A decrease in walking rate began between ages four and six. This decline was found to fit linear and monoexponential decay mode models equally. Average linear decay for all 15 patients was 0.0308 m/sec/month; and the average fractional decay was 0.0349/month. On average, by 10 years, the fast walking rate was reduced to about 29% of normal. This measure of disease progression followed a unique course in each subject, which could be mathematically characterized by a unique decay rate, and a unique walking velocity at age 10 years. Thus, in contrast to natural speed walking, the measurement of fast walking velocity has proved to be a simple and useful index for characterizing disease progression in Duchenne muscular dystrophy, and for evaluating therapeutic interventions.
对335名看似健康的受试者（180名男性和155名女性，年龄在3.5至24岁之间）测量了快走速度。这些速度随年龄增加，男性接近3.44米/秒的渐近线，女性接近3.17米/秒的渐近线，差异有统计学意义（p小于0.001）。还对15名杜氏肌营养不良症患者在18至132个月的时间段内进行了连续测量。步行速度在4至6岁之间开始下降。发现这种下降同样符合线性和单指数衰减模式模型。15名患者的平均线性衰减为0.0308米/秒/月；平均分数衰减为0.0349/月。平均而言，到10岁时，快走速度降至正常水平的约29%。这种疾病进展的测量在每个受试者中都遵循独特的过程，这可以通过独特的衰减率和10岁时独特的步行速度在数学上进行表征。因此，与自然快走不同，快走速度的测量已被证明是表征杜氏肌营养不良症疾病进展和评估治疗干预的一种简单而有用的指标。
