Matthias D, Becker C H, Woossmann H
Biomed Biochim Acta. 1984;43(6):741-8.
Spontaneously hypertensive rats (SHR) were found to tolerate the consequences of vitamin D intoxication much better than Wistar Kyoto rats (WKY). This is obvious from the 10-fold higher death rate of WKY rats and from the considerable differences of the tissue reactions occurring in the aorta, the cardiac muscle and the arterial vessels between WKY rats and SHR. Thus, myocardial alterations are much rarer in SHR; this holds also for the aorta calcification which is less pronounced in SHR and which is age-dependent in so far as it is almost absent from one year onward. Giant granulomas as a result of vitamin D intoxication were found in juvenile SHR at a time where they would otherwise no yet have occurred at a frequency observed in old untreated SHR. Common to both WKY rats and SHR is the formation of vascular alterations (plasmatic vasculosis) which reveal--though less pronounced with SHR--the angiotoxic action of vitamin D. For these considerable differences in the behaviour of WKY and SHR in vitamin D intoxication the different Ca-binding and transport properties of the arterial plasma membranes should be responsible, which is likely to be due to a defect in the Ca-transport mechanism of the smooth vascular muscle. The importance of these findings for the use of vitamin D intoxication in arteriosclerosis research as well as for studies on the pathogenesis of permeability disorders and alterations of the arterial vascular system is pointed out.
自发性高血压大鼠（SHR）被发现比Wistar Kyoto大鼠（WKY）对维生素D中毒的后果耐受得多。这从WKY大鼠10倍更高的死亡率以及WKY大鼠和SHR之间在主动脉、心肌和动脉血管中发生的组织反应的显著差异中可以明显看出。因此，SHR中心肌改变要少见得多；主动脉钙化也是如此，在SHR中不太明显，且与年龄有关，从一岁起几乎就不存在了。在幼年SHR中发现了由于维生素D中毒导致的巨大肉芽肿，而在未治疗的老年SHR中观察到的频率下，此时它们原本还不会出现。WKY大鼠和SHR的共同之处在于血管改变（血浆性血管病变）的形成，这揭示了维生素D的血管毒性作用，尽管在SHR中不太明显。对于WKY和SHR在维生素D中毒行为上的这些显著差异，动脉质膜不同的钙结合和转运特性应该是原因，这可能是由于平滑肌血管的钙转运机制存在缺陷。指出了这些发现对于在动脉硬化研究中使用维生素D中毒以及对通透性障碍发病机制和动脉血管系统改变的研究的重要性。
