一种新型生物活性有机硒化合物——I. PZ 51（依布硒啉）的体外谷胱甘肽过氧化物酶样活性及抗氧化能力
A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen).
作者信息
Müller A, Cadenas E, Graf P, Sies H
出版信息
Biochem Pharmacol. 1984 Oct 15;33(20):3235-9. doi: 10.1016/0006-2952(84)90083-2.
a synthetic seleno-organic compound, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ 51), exhibits GSH peroxidase-like activity in vitro, in contrast to its sulfur analog, PZ 25. In addition, PZ 51 behaves as an antioxidant shown by a temporary protection of rat liver microsomes against ascorbate/ADP-Fe-induced lipid peroxidation, an effect also elicited by PZ 25 but to a smaller extent. This protection against lipid peroxidation is independent of GSH and of P-450 monooxygenase activity.
一种合成的有机硒化合物，2-苯基-1,2-苯并异硒唑-3(2H)-酮（PZ 51），在体外表现出谷胱甘肽过氧化物酶样活性，这与其硫类似物PZ 25不同。此外，PZ 51表现为一种抗氧化剂，表现为对大鼠肝微粒体有短暂的保护作用，使其免受抗坏血酸/ADP-铁诱导的脂质过氧化，PZ 25也能引发这种效应，但程度较小。这种对脂质过氧化的保护作用不依赖于谷胱甘肽和P-450单加氧酶活性。
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