Ikejiri K, Yamada T, Ogura H
Diabetes. 1978 May;27(5):543-9. doi: 10.2337/diab.27.5.543.
In an attempt to study age-related metabolic abnormalities, glucose intolerance and serum insulin were examined in normal subjects and hyperthyroid patients. For comparison, serum concentrations of thyroxine (T4), triiodothyronine (T3), and total cholesterol were also measured in normal subjects and hyperthyroid patients. Although serum T4 concentration remained unchanged, serum T3 concentration decreased significantly in an elderly group of normal subjects. Similarly, serum T4 did not change with age and serum T3 decreased slightly but progressively with age in hyperthyroid patients. In addition, serum total cholesterol concentration increased progressively with age in normal subjects. Oral glucose tolerance decreased with age in normal subjects despite the same timing, peak level attained, and total magnitude of insulin response for old and young subjects. Although the severity of hyperthyroidism decreases with age, age-related glucose intolerance was much more apparent in hyperthyroid patients because of the age-related decrease of basal concentration, the peak level attained, and the total magnitude of insulin response. It is suggested that age-related glucose intolerance is magnified by the hyperthyroid state.
为了研究与年龄相关的代谢异常，对正常受试者和甲状腺功能亢进患者进行了葡萄糖耐量和血清胰岛素检测。作为比较，还测量了正常受试者和甲状腺功能亢进患者血清甲状腺素（T4）、三碘甲状腺原氨酸（T3）和总胆固醇的浓度。在老年正常受试者组中，尽管血清T4浓度保持不变，但血清T3浓度显著降低。同样，在甲状腺功能亢进患者中，血清T4不随年龄变化，血清T3随年龄略有但逐渐下降。此外，正常受试者血清总胆固醇浓度随年龄逐渐升高。尽管老年和年轻受试者的胰岛素反应时间、达到的峰值水平和总量相同，但正常受试者的口服葡萄糖耐量随年龄下降。尽管甲状腺功能亢进的严重程度随年龄降低，但由于基础浓度、达到的峰值水平和胰岛素反应总量的年龄相关性下降，年龄相关的葡萄糖耐量异常在甲状腺功能亢进患者中更为明显。提示甲状腺功能亢进状态会放大与年龄相关的葡萄糖耐量异常。
