静脉注射丙吡胺后口服缓释制剂进行维持治疗的药代动力学研究。
Maintenance therapy after i.v. administration of disopyramide with an oral sustained release preparation, a pharmacokinetic study.
作者信息
Liem K L, Hollander J M
出版信息
Br J Clin Pharmacol. 1984 Aug;18(2):226-8. doi: 10.1111/j.1365-2125.1984.tb02457.x.
The blood levels in 20 patients were studied during the change from parenteral administration of disopyramide to an oral sustained release preparation containing the same active substance. From this study it is concluded that 100 mg i.v. bolus injection of disopyramide can safely be followed by the immediate administration of one sustained release tablet containing 250 mg disopyramide. In case of an i.v. infusion (0.4 mg kg-1h-1) it seems wise not to start earlier with the administration of the sustained release preparation than at the moment of stopping the infusion.
在20名患者从胃肠外给予丙吡胺改为口服含有相同活性物质的缓释制剂的过程中，对其血药浓度进行了研究。从该研究得出结论，静脉推注100mg丙吡胺后，可以安全地立即给予一片含250mg丙吡胺的缓释片。对于静脉输注（0.4mg·kg-1·h-1）的情况，似乎明智的做法是，在停止输注时再开始给予缓释制剂，而不要更早开始。
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