普萘洛尔对映体与人α1-酸性糖蛋白及人血浆的立体选择性结合。
Stereoselective binding of propranolol enantiomers to human alpha 1-acid glycoprotein and human plasma.
作者信息
Albani F, Riva R, Contin M, Baruzzi A
出版信息
Br J Clin Pharmacol. 1984 Aug;18(2):244-6. doi: 10.1111/j.1365-2125.1984.tb02462.x.
Abstract
The binding of propranolol enantiomers to human albumin (ALB), alpha 1-acid glycoprotein (alpha 1-AGP) and plasma was studied. (-) propranolol is more bound than (+)propranolol to alpha 1-AGP (P less than 0.001) and to plasma (P less than 0.05). In solutions containing ALB at a constant concentration (580 mumol/l) and alpha 1-AGP at increasing concentrations, the binding of both isomers increases but the stereo selectivity is evident throughout the alpha 1-AGP concentration range examined (25-100 mumol/l).
摘要
研究了普萘洛尔对映体与人白蛋白（ALB）、α1-酸性糖蛋白（α1-AGP）及血浆的结合情况。（-）普萘洛尔比（+）普萘洛尔与α1-AGP的结合力更强（P<0.001），与血浆的结合力也更强（P<0.05）。在含有恒定浓度（580μmol/L）ALB和浓度递增的α1-AGP的溶液中，两种异构体的结合力均增加，但在所研究的α1-AGP浓度范围（25 - 100μmol/L）内，立体选择性均很明显。
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