一种客观评估咳嗽强度的肌电图方法以及使用该方法评估可待因对柠檬酸剂量反应曲线的影响。
An electromyographic method of objectively assessing cough intensity and use of the method to assess effects of codeine on the dose-response curve to citric acid.
作者信息
Cox I D, Wallis P J, Apps M C, Hughes D T, Empey D W, Osman R C, Burke C A
出版信息
Br J Clin Pharmacol. 1984 Sep;18(3):377-82. doi: 10.1111/j.1365-2125.1984.tb02479.x.
Abstract
The integrated surface abdominal electromyogram (EMG) has been used as a simple measurement of cough intensity which correlates well with the volume, air flow and noise produced in different coughs. Using the integrated abdominal EMG as a measure of cough intensity, dose response curves to inhaled citric acid can be drawn which are highly reproducible. We have studied the effects of codeine (60 mg) on these curves, and have demonstrated a reduction in cough intensity. It is suggested that this method of testing the effects of an antitussive on such a dose-response curve may be a useful one.
摘要
体表腹部肌电图（EMG）已被用作咳嗽强度的一种简单测量方法，它与不同咳嗽产生的音量、气流和噪音密切相关。以体表腹部肌电图作为咳嗽强度的衡量指标，可以绘制出对吸入柠檬酸的剂量反应曲线，这些曲线具有高度可重复性。我们研究了可待因（60毫克）对这些曲线的影响，并证明咳嗽强度有所降低。有人认为，这种测试镇咳药对此类剂量反应曲线影响的方法可能是一种有用的方法。
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本文引用的文献
1
Electromyographic study of patterns of activity of the anterior abdominal wall muscles in man.
J Anat. 1950 Apr;84(2):132-45.
2
The cough response of healthy human subjects stimulated by citric acid aerosol. II. Evaluation of antitussive agents.
Am J Med Sci. 1957 Aug;234(2):191-206. doi: 10.1097/00000441-195708000-00010.
3
Effect of antitussive agents on experimental and pathological cough in man.
J Appl Physiol. 1954 Sep;7(2):119-39. doi: 10.1152/jappl.1954.7.2.119.
4
The experimental production of cough in human subjects induced by citric acid aerosols; preliminary studies on the evaluation of antitussive agents.
Am J Med Sci. 1954 Aug;228(2):156-63. doi: 10.1097/00000441-195408000-00005.
5
The relation between force, velocity and integrated electrical activity in human muscles.
J Physiol. 1954 Jan;123(1):214-24. doi: 10.1113/jphysiol.1954.sp005044.
6
Regional differences in abdominal muscle activity during various maneuvers in humans.
J Appl Physiol Respir Environ Exerc Physiol. 1981 Dec;51(6):1471-6. doi: 10.1152/jappl.1981.51.6.1471.
7
Assessment of antitussive effects by citric acid threshold.
Br J Dis Chest. 1983 Jan;77(1):94-7.
8
Cough-monitoring equipment.
Med Res Eng. 1967;6(2):25-7.
9
Codeine kinetics as determined by radioimmunoassay.
Clin Pharmacol Ther. 1977 Oct;22(4):439-46. doi: 10.1002/cpt1977224439.
10
[Non-specific bronchial provocation tests in asthma (author's transl)].
Bull Eur Physiopathol Respir. 1976 Jul-Aug;12(4):565-98.
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