• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
An electromyographic method of objectively assessing cough intensity and use of the method to assess effects of codeine on the dose-response curve to citric acid.一种客观评估咳嗽强度的肌电图方法以及使用该方法评估可待因对柠檬酸剂量反应曲线的影响。
Br J Clin Pharmacol. 1984 Sep;18(3):377-82. doi: 10.1111/j.1365-2125.1984.tb02479.x.
2
Comparison of the antitussive effects of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects.使用柠檬酸诱发正常受试者咳嗽，比较20毫克磷酸可待因、30毫克右美沙芬和30毫克那可丁的镇咳效果。
Eur J Clin Pharmacol. 1979;16(6):393-7. doi: 10.1007/BF00568199.
3
Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig.咳嗽的动物模型：文献综述及一种新型豚鼠香烟烟雾增强咳嗽模型的介绍
Pulm Pharmacol Ther. 2007;20(4):325-33. doi: 10.1016/j.pupt.2006.12.001. Epub 2006 Dec 13.
4
The effect of codeine on the Urge-to-Cough response to inhaled capsaicin.可待因对吸入辣椒素引起的咳嗽冲动反应的影响。
Pulm Pharmacol Ther. 2007;20(4):338-46. doi: 10.1016/j.pupt.2006.10.012. Epub 2006 Oct 28.
5
Assessment of antitussive effects by citric acid threshold.通过柠檬酸阈值评估镇咳效果。
Br J Dis Chest. 1983 Jan;77(1):94-7.
6
Airway opioid receptors mediate inhibition of cough and reflex bronchoconstriction in guinea pigs.气道阿片受体介导豚鼠咳嗽抑制和反射性支气管收缩。
J Pharmacol Exp Ther. 1990 Feb;252(2):863-8.
7
The effect of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-induced cough in dogs.奈多罗米钠、色甘酸钠及磷酸可待因对柠檬酸诱发犬咳嗽的作用。
Br J Pharmacol. 1988 Mar;93(3):609-12. doi: 10.1111/j.1476-5381.1988.tb10317.x.
8
Assessment of the antitussive effect of vadocaine hydrochloride using citric acid-induced cough in healthy volunteers.在健康志愿者中使用柠檬酸诱导咳嗽评估盐酸瓦多卡因的镇咳作用。
Arzneimittelforschung. 1988 Apr;38(4A):639-41.
9
Diurnal variation and adaptation of the cough response to citric acid in normal subjects.正常受试者咳嗽反应对柠檬酸的昼夜变化及适应性
Thorax. 1985 Sep;40(9):657-61. doi: 10.1136/thx.40.9.657.
10
A noninvasive electromyographic study on threshold and intensity of cough in humans.一项关于人类咳嗽阈值和强度的无创肌电图研究。
Eur Respir J. 1997 May;10(5):983-9. doi: 10.1183/09031936.97.10050983.

引用本文的文献

1
The present and future of cough counting tools.咳嗽计数工具的现状与未来。
J Thorac Dis. 2020 Sep;12(9):5207-5223. doi: 10.21037/jtd-2020-icc-003.
2
Global Physiology and Pathophysiology of Cough: Part 1: Cough Phenomenology - CHEST Guideline and Expert Panel Report.全球咳嗽的生理学和病理生理学：第 1 部分：咳嗽现象学——CHEST 指南和专家报告。
Chest. 2021 Jan;159(1):282-293. doi: 10.1016/j.chest.2020.08.2086. Epub 2020 Sep 2.
3
Sound: a non-invasive measure of cough intensity.声音：一种咳嗽强度的非侵入性测量方法。
BMJ Open Respir Res. 2017 May 12;4(1):e000178. doi: 10.1136/bmjresp-2017-000178. eCollection 2017.
4
The effect of codeine on the Urge-to-Cough response to inhaled capsaicin.可待因对吸入辣椒素引起的咳嗽冲动反应的影响。
Pulm Pharmacol Ther. 2007;20(4):338-46. doi: 10.1016/j.pupt.2006.10.012. Epub 2006 Oct 28.
5
Capsaicin exposure elicits complex airway defensive motor patterns in normal humans in a concentration-dependent manner.辣椒素暴露以浓度依赖的方式在正常人体中引发复杂的气道防御运动模式。
Pulm Pharmacol Ther. 2007;20(4):423-32. doi: 10.1016/j.pupt.2006.11.006. Epub 2006 Dec 12.
6
Differences in motor activation of voluntary and reflex cough in humans.人类自主咳嗽和反射性咳嗽的运动激活差异。
Thorax. 2006 Aug;61(8):699-705. doi: 10.1136/thx.2005.057901. Epub 2006 Apr 6.
7
Relation between measurements of cough severity.咳嗽严重程度测量之间的关系。
Arch Dis Child. 2003 Jan;88(1):57-60. doi: 10.1136/adc.88.1.57.
8
Appropriate use of antitussives and protussives. A practical review.镇咳药与祛痰药的合理使用。实用综述。
Drugs. 1993 Jul;46(1):80-91. doi: 10.2165/00003495-199346010-00006.
9
Effects of inhaled budesonide on spirometric values, reversibility, airway responsiveness, and cough threshold in smokers with chronic obstructive lung disease.吸入布地奈德对慢性阻塞性肺疾病吸烟者肺量计值、可逆性、气道反应性和咳嗽阈值的影响。
Thorax. 1991 May;46(5):372-7. doi: 10.1136/thx.46.5.372.

本文引用的文献

1
Electromyographic study of patterns of activity of the anterior abdominal wall muscles in man.人体腹壁前侧肌肉活动模式的肌电图研究。
J Anat. 1950 Apr;84(2):132-45.
2
The cough response of healthy human subjects stimulated by citric acid aerosol. II. Evaluation of antitussive agents.柠檬酸气雾剂刺激下健康人体受试者的咳嗽反应。II. 镇咳药的评估。
Am J Med Sci. 1957 Aug;234(2):191-206. doi: 10.1097/00000441-195708000-00010.
3
Effect of antitussive agents on experimental and pathological cough in man.镇咳药对人体实验性和病理性咳嗽的影响。
J Appl Physiol. 1954 Sep;7(2):119-39. doi: 10.1152/jappl.1954.7.2.119.
4
The experimental production of cough in human subjects induced by citric acid aerosols; preliminary studies on the evaluation of antitussive agents.柠檬酸气雾剂诱发人体咳嗽的实验性研究；镇咳药评价的初步研究。
Am J Med Sci. 1954 Aug;228(2):156-63. doi: 10.1097/00000441-195408000-00005.
5
The relation between force, velocity and integrated electrical activity in human muscles.人体肌肉中力、速度与综合电活动之间的关系。
J Physiol. 1954 Jan;123(1):214-24. doi: 10.1113/jphysiol.1954.sp005044.
6
Regional differences in abdominal muscle activity during various maneuvers in humans.人体在各种动作过程中腹部肌肉活动的区域差异。
J Appl Physiol Respir Environ Exerc Physiol. 1981 Dec;51(6):1471-6. doi: 10.1152/jappl.1981.51.6.1471.
7
Assessment of antitussive effects by citric acid threshold.通过柠檬酸阈值评估镇咳效果。
Br J Dis Chest. 1983 Jan;77(1):94-7.
8
Cough-monitoring equipment.咳嗽监测设备。
Med Res Eng. 1967;6(2):25-7.
9
Codeine kinetics as determined by radioimmunoassay.通过放射免疫测定法测定的可待因动力学。
Clin Pharmacol Ther. 1977 Oct;22(4):439-46. doi: 10.1002/cpt1977224439.
10
[Non-specific bronchial provocation tests in asthma (author's transl)].哮喘的非特异性支气管激发试验（作者译）
Bull Eur Physiopathol Respir. 1976 Jul-Aug;12(4):565-98.

一种客观评估咳嗽强度的肌电图方法以及使用该方法评估可待因对柠檬酸剂量反应曲线的影响。

An electromyographic method of objectively assessing cough intensity and use of the method to assess effects of codeine on the dose-response curve to citric acid.

作者信息

Cox I D, Wallis P J, Apps M C, Hughes D T, Empey D W, Osman R C, Burke C A

出版信息

Br J Clin Pharmacol. 1984 Sep;18(3):377-82. doi: 10.1111/j.1365-2125.1984.tb02479.x.

DOI:10.1111/j.1365-2125.1984.tb02479.x
PMID:6487476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463642/
Abstract

The integrated surface abdominal electromyogram (EMG) has been used as a simple measurement of cough intensity which correlates well with the volume, air flow and noise produced in different coughs. Using the integrated abdominal EMG as a measure of cough intensity, dose response curves to inhaled citric acid can be drawn which are highly reproducible. We have studied the effects of codeine (60 mg) on these curves, and have demonstrated a reduction in cough intensity. It is suggested that this method of testing the effects of an antitussive on such a dose-response curve may be a useful one.

摘要

体表腹部肌电图（EMG）已被用作咳嗽强度的一种简单测量方法，它与不同咳嗽产生的音量、气流和噪音密切相关。以体表腹部肌电图作为咳嗽强度的衡量指标，可以绘制出对吸入柠檬酸的剂量反应曲线，这些曲线具有高度可重复性。我们研究了可待因（60毫克）对这些曲线的影响，并证明咳嗽强度有所降低。有人认为，这种测试镇咳药对此类剂量反应曲线影响的方法可能是一种有用的方法。