Shih C, Higuchi T, Himmelstein K J
Biomaterials. 1984 Jul;5(4):237-40. doi: 10.1016/0142-9612(84)90022-x.
The incorporation of small amounts of acid anhydrides into hydrophobic poly(ortho ester)s can facilitate the erosion and drug release from delivery systems. Since the reaction can be controlled by the amount of anhydride employed, the reaction is confined to a small reaction zone near the surface and constant delivery rates can be achieved. The catalytic activity is negatively correlated with the pKa of the corresponding acid of the anhydride.
将少量酸酐掺入疏水性聚原酸酯中可促进药物从给药系统中的溶蚀和释放。由于该反应可通过所用酸酐的量来控制，反应局限于表面附近的一个小反应区域，从而可实现恒定的释放速率。催化活性与酸酐相应酸的pKa呈负相关。
