Vaupel P, Müller-Klieser W
Biorheology. 1984;21(4):521-8. doi: 10.3233/bir-1984-21411.
Experiments are performed to study the influence of local hemodilution on tumor blood flow, oxygen availability in tumor tissue and O2 consumption of cancer cells. The results obtained clearly show that hemodilution in isolated tumor perfusion can distinctly improve nutritive blood flow through solid tumors. This can be utilized to enhance pharmacokinetics of antitumor drugs. Due to the improved metabolic status, the pharmacodynamics of some antitumor drugs should also be enhanced. To achieve a maximum improvement of the O2 supply to the tumor, hematocrit values should not be decreased below 0.20.
进行实验以研究局部血液稀释对肿瘤血流、肿瘤组织中的氧供应以及癌细胞的氧消耗的影响。所获得的结果清楚地表明，在离体肿瘤灌注中进行血液稀释可显著改善通过实体瘤的营养性血流。这可用于增强抗肿瘤药物的药代动力学。由于代谢状态的改善，一些抗肿瘤药物的药效学也应得到增强。为了最大程度地改善肿瘤的氧供应，血细胞比容值不应降低至低于0.20。
