McCarey B E, Schmidt F H, Wilkinson K D, Baum J P
Curr Eye Res. 1984 Aug;3(8):977-89. doi: 10.3109/02713688409011744.
Soft contact lenses have been used as therapeutic bandages to aid epithelial healing following pentrating keratoplasty. Often the hydrogel lenses are used in conjunction with topical medications such as gentamicin. A reported complication is the persistence of infectious ulcers even though the eye is being treated with topical antibiotics. The purpose of this study was to measure the gentamicin diffusion coefficients for some hydrogel bandage lenses and to design a kinetic model to estimate the drug distribution on an eye covered with a hydrogel contact lens. The model includes the hydrogel diffusion coefficients and literature values for tear production, tear exchange per blink around the edge of a lens, fit, etc. From the computer generated data, it can be shown that the permeability of gentamicin sulfate through the Saulfon-80 hydrogel lens on a normal eye was only 0.002% of the amount of the drug under the contact lens after 10 minute intervals of topical drug application. The important drug distribution pathway was around the edge of the lens.
软性隐形眼镜已被用作治疗性绷带，以辅助穿透性角膜移植术后的上皮愈合。水凝胶镜片通常与庆大霉素等局部用药联合使用。据报道，即使眼部正在使用局部抗生素治疗，仍会出现感染性溃疡持续存在的并发症。本研究的目的是测量一些水凝胶绷带镜片的庆大霉素扩散系数，并设计一个动力学模型来估计药物在覆盖有水凝胶隐形眼镜的眼睛上的分布情况。该模型包括水凝胶扩散系数以及泪液分泌、眨眼时镜片边缘周围的泪液交换、适配性等的文献值。从计算机生成的数据可以看出，在正常眼睛上，局部用药间隔10分钟后，硫酸庆大霉素透过Saulfon - 80水凝胶镜片的渗透率仅为隐形眼镜下药物量的0.002%。重要的药物分布途径是围绕镜片边缘。
