Miller W C, Heard J G, Unger K M
Chest. 1984 Nov;86(5):704-6. doi: 10.1378/chest.86.5.704.
Among 27 patients with moderate-to-severe chronic obstructive lung disease, 22 had anatomic intrapulmonary shunting greater than that seen in normal subjects. The shunted blood passed through enlarged pulmonary vessels, as demonstrated with particles 10-90 microns in diameter. The shunt magnitude was correlated with the decrement in lung diffusing capacity. It did not correlate well with pulmonary mechanical abnormalities such as air flows and volumes or resting blood gas data. Nevertheless, shunting through enlarged pulmonary vessels may play a role in the hypoxemia seen in COPD patients, especially at exercise.
在27例中重度慢性阻塞性肺疾病患者中，22例存在解剖学上的肺内分流，其程度大于正常受试者。分流的血液通过扩张的肺血管，这一点通过直径为10 - 90微米的微粒得以证实。分流程度与肺弥散能力的降低相关。它与诸如气流、肺容积等肺力学异常或静息血气数据的相关性不佳。然而，通过扩张的肺血管进行的分流可能在慢性阻塞性肺疾病患者的低氧血症中起作用，尤其是在运动时。
