Mårtensson J, Nilsson L, Sörbo B
FEBS Lett. 1984 Oct 29;176(2):334-6. doi: 10.1016/0014-5793(84)81191-6.
Rat brain mitochondria were found to convert 3-mercaptopyruvate to 2-mercaptoacetate in the presence of NAD+, coenzyme A and thiamin pyrophosphate. The overall reaction probably consists of an oxidative decarboxylation of 3-mercaptopyruvate with 2-mercaptoacetyl CoA as a product which is then hydrolyzed to 2-mercaptoacetate by acyl CoA hydrolase.
研究发现，大鼠脑线粒体在存在烟酰胺腺嘌呤二核苷酸（NAD⁺）、辅酶A和硫胺素焦磷酸的情况下，可将3-巯基丙酮酸转化为2-巯基乙酸。整个反应可能包括3-巯基丙酮酸的氧化脱羧反应，生成产物2-巯基乙酰辅酶A，然后该产物被酰基辅酶A水解酶水解为2-巯基乙酸。
