Liu M S, Spitzer J J
Horm Metab Res. 1978 Mar;10(2):114-7. doi: 10.1055/s-0028-1093455.
Myocardial homogenates from control of alloxan-diabetic dogs were incubated in the presence of lactate or palmitate as the sole substrate. The rate of lactate oxidation of the homogenates from diabetic dogs was less than half of the oxidation rate of homogenates from control animals. The incorporation of labelled palmitate into triglyceride was greatly enhanced in the heart taken from diabetic animals. The tissue concentration of l-carnitine was twice and that of triglyceride was three times as high in the diabetic animals as in their control counterparts. Thus the myocardium of diabetic animals exhibited both altered substrate utilization and increased rate of triglyceride synthesis.
将来自正常犬和四氧嘧啶糖尿病犬的心肌匀浆，分别在以乳酸盐或棕榈酸盐作为唯一底物的条件下进行孵育。糖尿病犬心肌匀浆的乳酸氧化速率不到正常动物心肌匀浆氧化速率的一半。在取自糖尿病动物的心脏中，标记棕榈酸盐掺入甘油三酯的过程显著增强。糖尿病动物体内的左旋肉碱组织浓度是正常对照动物的两倍，甘油三酯浓度则是三倍。因此，糖尿病动物的心肌既表现出底物利用的改变，又表现出甘油三酯合成速率的增加。
