Gamble J G
J Pediatr Orthop. 1984 Sep;4(5):585-9.
Two cases of Hutchinson-Gilford progeria syndrome are presented with a focus on hip disease. A severe coxa valga is the first abnormality. The femoral head becomes increasingly uncovered as the acetabulum becomes more dysplastic. The center edge angle decreases, the acetabular index increases, and the medial wall of the acetabulum widens. Hip pain, subluxation, and eventually dislocation are the sequelae of these changes. Late osteotomy is unpredictable; thus the best therapeutic regimen is early osteotomy (age 4-6 years) and a regular exercise program to maintain muscle strength and range of motion.
本文报告两例哈钦森-吉尔福德早衰综合征病例，重点关注髋关节疾病。严重的髋外翻是首要异常表现。随着髋臼发育不良加重，股骨头逐渐外露。中心边缘角减小，髋臼指数增加，髋臼内壁增宽。这些变化的后果是髋关节疼痛、半脱位，最终发展为脱位。晚期截骨术效果难以预测；因此，最佳治疗方案是早期截骨术（4 - 6岁）以及定期进行锻炼计划以维持肌肉力量和活动范围。
