Wilfert C M, MacCormack J N, Kleeman K, Philip R N, Austin E, Dickinson V, Turner L
J Infect Dis. 1984 Oct;150(4):469-79. doi: 10.1093/infdis/150.4.469.
Prospective, active surveillance for Rocky Mountain Spotted fever (RMSF) was undertaken in two North Carolina counties for the years 1979-1981. Appropriate age, sex, and geographically matched controls were compared with the serologically confirmed cases of disease. Patients who were suspected of having infection, but were shown not to have RMSF, were also compared with the serologically proven cases. Ninety-eight cases were identified, and three of these patients died. The mean annual incidence of RMSF in these two counties was 14.59 cases/100,000 population. Identified cases occurred between the months of March and September. The overall mean annual incidence for men was 19.65/100,000 and for women 10.3/100,000. The study suggests that persons contracting RMSF are exposed to the vectors at their residences, which tend to be detached dwellings in woody, brushy areas. Children are more likely than adults both to be seen by physicians early in the illness and to be checked for ticks. Eighty-four percent of patients with serologically confirmed cases developed a rash. The epidemiology of RMSF in these two endemic counties is described.
1979年至1981年期间，在北卡罗来纳州的两个县对落基山斑疹热（RMSF）进行了前瞻性主动监测。将年龄、性别和地理位置匹配的合适对照与血清学确诊的疾病病例进行比较。对疑似感染但未患RMSF的患者也与血清学证实的病例进行了比较。共确诊98例病例，其中3例患者死亡。这两个县RMSF的年平均发病率为每10万人14.59例。确诊病例发生在3月至9月之间。男性的总体年平均发病率为每10万人19.65例，女性为每10万人10.3例。该研究表明，感染RMSF的人是在其住所接触到传播媒介的，这些住所往往是树木繁茂、灌木丛生地区的独立住宅。儿童比成年人更有可能在疾病早期被医生诊治并接受蜱虫检查。血清学确诊病例中有84%出现了皮疹。本文描述了这两个流行县RMSF的流行病学情况。
