Brotman B, Prince A M
J Infect Dis. 1984 Nov;150(5):714-20. doi: 10.1093/infdis/150.5.714.
Positive AUSAB test results in the absence of all other serological markers for hepatitis B have been seen frequently in serial serum specimens from quarantined chimpanzees. In this study the responsible reactant was found to be similar to IgM in terms of both size and charge. After the inoculation of hepatitis B virus, AUSAB-positive and AUSAB-negative chimpanzees were found to be equally susceptible to hepatitis B infection. Thus, the presence of this reactant did not confer immunity to hepatitis B or modulate the course of the disease. At present, hepatitis B virus-seronegative chimpanzees are excluded from use in research on hepatitis B because of the occurrence of this "false-positive" AUSAB test result. It is likely that humans may be denied active or passive immunization for similar reasons.
在来自隔离黑猩猩的系列血清标本中，经常可以看到在没有其他所有乙肝血清学标志物的情况下，AUSAB检测结果呈阳性。在本研究中，发现这种起反应的物质在大小和电荷方面都与IgM相似。接种乙肝病毒后，发现AUSAB阳性和AUSAB阴性的黑猩猩对乙肝感染同样易感。因此，这种反应物质的存在并不能赋予对乙肝的免疫力或调节疾病进程。目前，由于这种“AUSAB检测假阳性”结果的出现，乙肝病毒血清学阴性的黑猩猩被排除在乙肝研究之外。人类也可能因类似原因而无法进行主动或被动免疫。
