Murch A R, Grounds M D, Papadimitriou J M
J Pathol. 1984 Oct;144(2):81-7. doi: 10.1002/path.1711440203.
The origin of resident peritoneal macrophages was studied in radiation mouse chimaeras with and without reconstitution of the peritoneum with viable isogeneic peritoneal cells. The selection of host and donor strains were such that the isoenzymes of glucose-6-phosphate isomerase could be used to distinguish host from donor bone marrow derived cells. It was found that the resident peritoneal macrophages were completely replaced by bone marrow donor derived cells within 5-6 weeks. There was little difference between the results from mice which had been additionally reconstituted with peritoneal cells and those which were not.
在有或没有用活的同基因腹膜细胞重建腹膜的辐射小鼠嵌合体中，研究了驻留腹膜巨噬细胞的起源。宿主和供体菌株的选择使得葡萄糖-6-磷酸异构酶的同工酶可用于区分宿主和供体骨髓来源的细胞。结果发现，驻留腹膜巨噬细胞在5-6周内完全被骨髓供体来源的细胞所取代。用腹膜细胞额外重建的小鼠和未重建的小鼠的结果几乎没有差异。
