Omar A M, Eshba N H
J Pharm Sci. 1984 Aug;73(8):1166-8. doi: 10.1002/jps.2600730837.
A novel series of 2-arylimino-2,3-dihydrothiazole derivatives, substituted in the 3-position with a beta-phenethyl moiety and the 4-position with substituted aryl functions, was synthesized as potential antimicrobial, antihypertensive and anticonvulsive agents. While no antimicrobial or significant antihypertensive activity was observed for the products, XII, XIII, and XXI displayed potent anticonvulsant activity.
合成了一系列新型的2-芳基亚氨基-2,3-二氢噻唑衍生物,其3位被β-苯乙基部分取代,4位被取代的芳基官能团取代,作为潜在的抗菌、抗高血压和抗惊厥剂。虽然未观察到产物具有抗菌或显著的抗高血压活性,但化合物XII、XIII和XXI表现出强效的抗惊厥活性。