Hussain A A, Kimura R, Huang C H
J Pharm Sci. 1984 Sep;73(9):1300-1. doi: 10.1002/jps.2600730929.
Testosterone levels in the blood were determined in rats following nasal, intravenous, and intraduodenal administration of 25-micrograms and 50-micrograms doses. The results indicated that the drug levels after nasal and intravenous administration were similar, whereas intraduodenal administration resulted in considerably lower levels. The bioavailability of the nasally administered drug was calculated to be 99% and 90% at the 25-micrograms and 50-micrograms doses, respectively. The intraduodenal bioavailability was only 1% at the dose studied.
在大鼠经鼻腔、静脉和十二指肠给予25微克和50微克剂量后，测定其血液中的睾酮水平。结果表明，鼻腔给药和静脉给药后的药物水平相似，而十二指肠给药后的水平则显著较低。经计算，鼻腔给药药物在25微克和50微克剂量时的生物利用度分别为99%和90%。在所研究的剂量下，十二指肠给药的生物利用度仅为1%。
