采用高效液相色谱法测定左甲状腺素钠原料药、片剂和注射剂中的含量。
Determination of sodium levothyroxine in bulk, tablet, and injection formulations by high-performance liquid chromatography.
作者信息
Brower J F, Toler D Y, Reepmeyer J C
出版信息
J Pharm Sci. 1984 Sep;73(9):1315-7. doi: 10.1002/jps.2600730937.
PMID:6491963
Abstract
Sodium levothyroxine was determined in bulk drugs, tablets, and injections by high-performance liquid chromatography (HPLC). Levothyroxine was separated from excipients and impurities on a 10-microns cyanoalkyl column using an acetonitrile-water-phosphoric acid mobile phase. The HPLC method is shown to be linear, accurate, and precise, and the results obtained by the HPLC and USP XX methods are compared.
摘要
采用高效液相色谱法（HPLC）对左甲状腺素钠原料药、片剂和注射剂进行测定。使用乙腈 - 水 - 磷酸流动相，在10微米氰基烷基柱上，左甲状腺素与辅料和杂质分离。结果表明，该HPLC方法具有线性、准确性和精密度，并对HPLC法和美国药典XX方法所得结果进行了比较。
Zotero 插件