Targovnik H S, Locher S E, Hart T F, Hariharan P V
Mech Ageing Dev. 1984 Sep;27(1):73-81. doi: 10.1016/0047-6374(84)90083-6.
Excision repair capacity was measured in the free-living nematode Turbatrix aceti, a model aging system. Excision repair was assessed by both repair synthesis activity and the actual removal of pyrimidine dimers from the genome. The young organisms removed lesions more rapidly and completely than the old for all fluences tested. Repair synthesis began and peaked earlier for young nematodes than old. The data consistently indicated a decline in DNA excision repair capacity with age in the nematode.
在自由生活的线虫醋线虫（一种衰老模型系统）中测量了切除修复能力。通过修复合成活性和从基因组中实际去除嘧啶二聚体来评估切除修复。对于所有测试的辐射剂量，年轻生物体比年老生物体更快、更完全地去除损伤。年轻线虫的修复合成开始时间和达到峰值的时间都比年老线虫早。数据一致表明，线虫的DNA切除修复能力会随着年龄的增长而下降。
