人类淋巴细胞中的突变频率随年龄增长而增加。

Mutation frequency in human lymphocytes increases with age.

作者信息

Trainor K J, Wigmore D J, Chrysostomou A, Dempsey J L, Seshadri R, Morley A A

出版信息

Mech Ageing Dev. 1984 Sep;27(1):83-6. doi: 10.1016/0047-6374(84)90084-8.

Abstract

Several theories of ageing predict that somatic mutations should increase with age. This prediction was tested for human lymphocytes using a recently developed clonal technique for enumeration of mutations, and an increase of 1.6% per year in mutations with age was detected.

摘要

几种衰老理论预测，体细胞突变应随年龄增长而增加。利用最近开发的一种用于计数突变的克隆技术，对人类淋巴细胞进行了这一预测的测试，并检测到突变随年龄每年增加1.6%。