Jeng I
Life Sci. 1984 Nov 19;35(21):2143-8. doi: 10.1016/0024-3205(84)90514-9.
Butyrate induced marked morphological changes in cultured human retinal pigment epithelial (RPE) cells. The cells assumed a flattened structure within six hours of exposure to butyrate. The butyrate-treated retinal pigment epithelial cells possessed an enhanced capacity to esterify retinol. Among all short chain organic acids tested, butyrate was by far the most effective, followed by pentanoate and hexanoate. The inductive effect of butyrate was specific for retinol esterification, since the incorporations of fatty acid into phosphatidyl choline and cholesteryl ester were not enhanced. Time-dependent, butyrate-enhanced retinol esterification may be related to the inhibition of cell proliferation. This represents the first report on the induction of retinol esterification in cultured retinal pigment epithelial cells.
丁酸盐可诱导培养的人视网膜色素上皮（RPE）细胞发生显著的形态变化。在接触丁酸盐六小时内，细胞呈现出扁平结构。经丁酸盐处理的视网膜色素上皮细胞酯化视黄醇的能力增强。在所有测试的短链有机酸中，丁酸盐的效果最为显著，其次是戊酸盐和己酸盐。丁酸盐的诱导作用对视黄醇酯化具有特异性，因为脂肪酸掺入磷脂酰胆碱和胆固醇酯并未增强。丁酸盐增强视黄醇酯化的作用具有时间依赖性，可能与细胞增殖的抑制有关。这是关于培养的视网膜色素上皮细胞中视黄醇酯化诱导作用的首次报道。
