Pettersson A, Persson B, Henning M, Hedner T
Naunyn Schmiedebergs Arch Pharmacol. 1984 Aug;327(1):43-7. doi: 10.1007/BF00504990.
The effects of chronic oral treatment with the 5-hydroxytryptamine (serotonin) receptor blocking agent ketanserin (17 mg/100 g dry food) on blood pressure, heart weight, peripheral vascular reactivity, baroreceptor sensitivity, central cardiovascular reactivity and central catecholamine turnover were investigated in the spontaneously hypertensive rat. Blood pressure measurements were performed in conscious rats 24 h after insertion of catheters. After 6 weeks treatment basal blood pressure was reduced (16%) compared to control rats (given identical food, except for ketanserin). Both heart weight and body weight were reduced (both to 93% of control values) leaving heart weight/body weight ratio unchanged. Pressor responses to phenylephrine and depressor responses to isoprenaline (after pretreatment with reserpine and atropin) were not different while the blood pressure increase to 5-hydroxytryptamine was inhibited, indicating that after 6 weeks treatment the blood pressure reduction is not directly related to alpha-adrenoceptor blockade. Cardiovascular response to stress (jet air), baroreceptor sensitivity (bradycardia to phenylephrine) and central catecholamine synthesis rates (accumulation of 5-hydroxytryptophan and dihydroxyphenylalanine after synthesis inhibition) were unchanged supporting earlier evidence that central mechanisms probably do not contribute to the hypotensive effects of ketanserin.
在自发性高血压大鼠中，研究了5-羟色胺（血清素）受体阻断剂酮色林（17毫克/100克干粮）长期口服治疗对血压、心脏重量、外周血管反应性、压力感受器敏感性、中枢心血管反应性和中枢儿茶酚胺周转率的影响。在有意识的大鼠插入导管24小时后测量血压。治疗6周后，与对照大鼠（给予除酮色林外相同的食物）相比，基础血压降低（16%）。心脏重量和体重均降低（均降至对照值的93%），而心脏重量/体重比不变。对去氧肾上腺素的升压反应和对异丙肾上腺素的降压反应（在用利血平和阿托品预处理后）没有差异，而对5-羟色胺的血压升高受到抑制，这表明治疗6周后血压降低与α-肾上腺素能受体阻断没有直接关系。对压力（喷气）的心血管反应、压力感受器敏感性（对去氧肾上腺素的心动过缓）和中枢儿茶酚胺合成率（合成抑制后5-羟色氨酸和二羟基苯丙氨酸的积累）没有变化，这支持了早期的证据，即中枢机制可能对酮色林的降压作用没有贡献。
