Rommelspacher H, Damm H, Strauss S, Schmidt G
Naunyn Schmiedebergs Arch Pharmacol. 1984 Sep;327(2):107-13. doi: 10.1007/BF00500903.
Harman occurs in rat brain, with the highest concentration in the cerebellum and the lowest in the striatum. 2 g/kg ethanol were ineffective with respect to the concentration of harman in the brain whereas 5 g/kg ethanol caused a time-dependent increase in the cerebral cortex as well as the cerebellum. A toxic dose (8 g/kg) of ethanol elicited no change of harman in the brain 3 h following the application. The rise in the harman concentration in the brain did not correlate with the increase of acetaldehyde in the blood after treatment with ethanol suggesting that several mechanisms are involved in the changes of the levels of harman. In subchronic experiments rats were treated with ethanol over a period of 5 or 6 days. Harman increased in the brain whereby the effect seemed to be more pronounced in the cerebellum than in the cerebral cortex. The concentration tended to increase over time and reached control levels again during withdrawal. The time course of the excretion of harman into the urine was similar to that of the brain in that it increased continuously during the period of ethanol treatment and reached control levels again during withdrawal.
哈尔满存在于大鼠大脑中，在小脑中浓度最高，在纹状体中浓度最低。2克/千克乙醇对大脑中哈尔满的浓度没有影响，而5克/千克乙醇会使大脑皮层和小脑中的哈尔满浓度随时间增加。8克/千克的乙醇中毒剂量在给药后3小时对大脑中的哈尔满没有影响。乙醇处理后，大脑中哈尔满浓度的升高与血液中乙醛的增加无关，这表明哈尔满水平的变化涉及多种机制。在亚慢性实验中，大鼠接受乙醇处理5或6天。大脑中的哈尔满增加，其中小脑的影响似乎比大脑皮层更明显。浓度随时间趋于增加，并在戒断期间再次达到对照水平。哈尔满排泄到尿液中的时间进程与大脑相似，即在乙醇处理期间持续增加，并在戒断期间再次达到对照水平。
