Lavaud S, Mamez B, Lavaud F, Birembaut P, Toupance O, Brunois J P, Chanard J
Nephrologie. 1984;5(3):131-4.
Renal involvement is not frequently observed during therapy with clometacine and its mechanism not fully understood. We report on a case of acute renal failure occurring four times in conjunction with acute hepatitis before the causative effect of clometacine was demonstrated. Drug hypersensitivity was documented by anatomical findings consisting in renal interstitial infiltration by mononuclear cells and eosinophils and by hypereosinophilia, increase in plasma IgE and a positive basophil degranulation test.
在使用氯美他嗪治疗期间，肾脏受累情况并不常见，其机制也尚未完全明确。我们报告了一例在证实氯美他嗪的致病作用之前，急性肾衰竭与急性肝炎一同出现四次的病例。药物超敏反应通过解剖学发现得以证实，表现为肾间质单核细胞和嗜酸性粒细胞浸润、嗜酸性粒细胞增多、血浆IgE升高以及嗜碱性粒细胞脱颗粒试验呈阳性。
