Oishi M, Inagaki C, Takaori S
Neuropeptides. 1984 Sep;4(5):351-9. doi: 10.1016/0143-4179(84)90110-0.
Triphasic depressor-pressor-depressor blood pressure responses to neurotensin (NT: 1.67 micrograms/kg i.v.) in anesthetized rats were not elicited when the second dose of NT was administered 20 min after the first injection. Pretreatment of animals with histamine markedly reduced the depressor response to NT, and vice versa. The triphasic blood pressure pattern remained unaffected with acetylcholine and serotonin treatment, and hypotensive effects of acetylcholine and serotonin were not modified by NT. Attenuation of depressor response induced by the second injection of NT was antagonized by pretreatment with prostaglandin synthesis inhibitors such as indomethacin, mefenamic acid and acetylsalicylic acid. These results suggest that histamine and prostaglandins play a role in the development of desensitization to NT in rat blood pressure.
在麻醉大鼠中，当在首次注射神经降压素（NT：1.67微克/千克静脉注射）20分钟后给予第二剂NT时，未引发三相降压-升压-降压血压反应。用组胺预处理动物可显著降低对NT的降压反应，反之亦然。乙酰胆碱和血清素处理后，三相血压模式未受影响，且乙酰胆碱和血清素的降压作用未被NT改变。用吲哚美辛、甲芬那酸和乙酰水杨酸等前列腺素合成抑制剂预处理可拮抗第二次注射NT引起的降压反应减弱。这些结果表明，组胺和前列腺素在大鼠血压对NT脱敏的发生中起作用。
