维拉帕米对弓状核-正中隆起复合体中钾离子诱发的内源性多巴胺释放的双重作用。

Dual effect of verapamil on K+-evoked release of endogenous dopamine from arcuate nucleus-median eminence complex.

作者信息

Di Renzo G, Amoroso S, Taglialatela M, Annunziato L

出版信息

Neurosci Lett. 1984 Sep 7;50(1-3):269-72. doi: 10.1016/0304-3940(84)90497-x.

Abstract

The effect of verapamil, a calcium-entrance blocker, on K+-evoked release of endogenous dopamine from tuberoinfundibular neurons incubated in vitro was studied. This compound, added to the incubation medium, at the dose of 10(-6) M, significantly reinforced K+-induced dopamine release, whereas, at higher doses (10(-5), 5 X 10(-5) and 10(-4) M), it completely prevented the stimulated dopamine release. The results obtained with the higher doses showed the calcium dependence of K+-evoked release of endogenous dopamine from central neurons. The opposite effect, seen with the lower dose of verapamil, could be due to different pharmacological properties of the drug.

摘要

研究了钙通道阻滞剂维拉帕米对体外培养的结节漏斗神经元中钾离子诱发内源性多巴胺释放的影响。将该化合物添加到孵育培养基中，剂量为10(-6)M时，可显著增强钾离子诱导的多巴胺释放，而在较高剂量（10(-5)、5×10(-5)和10(-4)M）时，它完全抑制了刺激引起的多巴胺释放。高剂量时获得的结果表明，中枢神经元中钾离子诱发内源性多巴胺释放具有钙依赖性。维拉帕米低剂量时出现的相反作用可能归因于该药物不同的药理特性。