Peng D R, Birgersson C, von Bahr C, Rane A
Pediatr Pharmacol (New York). 1984;4(3):155-9.
The N-acetylation of the reduced metabolite of clonazepam 7-amino-clonazepam was studied in cytosolic preparation from human fetal and adult livers. The metabolite formed 7-acetamido-clonazepam was measured with high performance liquid chromatography. A bimodal distribution of the N-acetyltransferase activities was observed in cytosols from human adult livers. These activities were 117 +/- 11 and 27 +/- 16 pmoles X mg-1 X min-1 for rapid and slow acetylators, respectively. The data observed in the fetal specimens did not allow any conclusion about bimodality because of a low number of samples.
在人胎儿和成人肝脏的胞质制备物中研究了氯硝西泮还原代谢物7-氨基氯硝西泮的N-乙酰化作用。用高效液相色谱法测定形成的代谢物7-乙酰氨基氯硝西泮。在成人肝脏的胞质溶胶中观察到N-乙酰转移酶活性的双峰分布。对于快速和慢速乙酰化者，这些活性分别为117±11和27±16 pmol×mg-1×min-1。由于样本数量少，在胎儿标本中观察到的数据无法得出关于双峰性的任何结论。
