对乙酰氨基酚在人体中的胆汁和肾脏排泄。

Biliary and renal excretion of paracetamol in man.

作者信息

Siegers C P, Loeser W, Gieselmann J, Oltmanns D

出版信息

Pharmacology. 1984;29(5):301-3. doi: 10.1159/000138026.

Abstract

In 6 postsurgery patients with T tubes inserted in their common bile ducts, biliary excretion of paracetamol amounted to 2.6% of an oral dose (1 g), consisting of unchanged paracetamol (0.57%) and conjugates of sulfate (0.36%), glucuronic acid (0.36%) and cysteine (1.63%). Renal recovery in the same patients was 35.3%, consisting of 2.6% unchanged paracetamol, 12.7% paracetamol sulfate, 9.0% glucuronide, 3.9% cysteine conjugate and 4.0% mercapturate.

摘要

在6例术后胆总管插入T管的患者中，对乙酰氨基酚的胆汁排泄量占口服剂量（1g）的2.6%，其中包括未变化的对乙酰氨基酚（0.57%）以及硫酸盐（0.36%）、葡萄糖醛酸（0.36%）和半胱氨酸（1.63%）的结合物。同一批患者中对乙酰氨基酚经肾回收的比例为35.3%，包括2.6%未变化的对乙酰氨基酚、12.7%的对乙酰氨基酚硫酸盐、9.0%的葡萄糖醛酸苷、3.9%的半胱氨酸结合物和4.0%的硫醚氨酸。