高自我刺激者和低自我刺激者的视觉诱发电位与痛觉阈值

Visual evoked potentials and nociceptive thresholds in high and low self-stimulators.

作者信息

Levin D, Frenk H, Myslobodsky M

出版信息

Physiol Behav. 1984 May;32(5):887-9. doi: 10.1016/0031-9384(84)90212-9.

Abstract

Tail flick latencies (TFL) were examined in order to distinguish between rats from genetically high (HI) and low (LO) self-stimulation lines (LC2-HI and LC2-LO). In addition, slow secondary negative wave (SNW) of the visual evoked potential, which is considered to be a sensitive index of normal and pharmacologically-induced behavioral arousal, was analysed. Small, albeit statistically significant enhancement of SNW was obtained in LO rats. Unlike LO animals, HI rats gained in SNW amplitude during repeated photic stimulation. The difference between the lines was highly significant. TFL assessment yielded slightly reduced (NS) values for HI rats. However, when TFL and SNW data were compared it appeared that TFL vary as a function of SNW amplitude in LO but not in HI rats, (r = 0.9). SNW may be employed as a predictor of the nociceptive threshold in rats.

摘要

为了区分来自基因高（HI）和低（LO）自我刺激品系（LC2-HI和LC2-LO）的大鼠，对甩尾潜伏期（TFL）进行了检测。此外，还分析了视觉诱发电位的慢二级负波（SNW），它被认为是正常和药物诱导行为觉醒的敏感指标。在LO大鼠中，虽然SNW有统计学意义的小幅增强。与LO动物不同，HI大鼠在重复光刺激期间SNW振幅增加。品系之间的差异非常显著。HI大鼠的TFL评估值略有降低（无统计学意义）。然而，当比较TFL和SNW数据时，发现TFL在LO大鼠中随SNW振幅变化，而在HI大鼠中则不然（r = 0.9）。SNW可作为大鼠伤害性感受阈值的预测指标。