Baumgarten C, Kunkel G, Rudolph R
Respiration. 1984;46(1):97-104. doi: 10.1159/000194676.
In an open comparative study with 31 grass pollen-allergic patients, two allergen extracts ('allergoid' extract/semi-depot extract) were examined. In the 1st year of treatment the allergoid group showed better results in relation to symptom score, drug consumption and IgG response, however, in the course of further treatment this difference was not evident anymore. Treatment was successful in both groups. A significant correlation between total antigen dose and IgG response was found. The better clinical results for the allergoid group in the first season after the 1st and 4th year of observation do indicate a better long-term therapeutic effect compared to the semi-depot group. This finding probably is due to the much higher antigen dose (4-fold) in the allergoid group.
在一项针对31名草花粉过敏患者的开放性对照研究中，对两种变应原提取物（“类变应原”提取物/半长效提取物）进行了检查。在治疗的第一年，类变应原组在症状评分、药物消耗和IgG反应方面显示出更好的结果，然而，在进一步治疗过程中，这种差异不再明显。两组治疗均成功。发现总抗原剂量与IgG反应之间存在显著相关性。在观察的第1年和第4年后的第一个季节，类变应原组更好的临床结果确实表明与半长效组相比具有更好的长期治疗效果。这一发现可能是由于类变应原组中抗原剂量高得多（4倍）。
