Lidman D, Lyczakowski T, Daniel R K
Scand J Plast Reconstr Surg. 1984;18(2):187-92. doi: 10.3109/02844318409052836.
End-to-end microvascular suture anastomoses, 40 arterial and 41 venous, from the rabbits carotid artery and posterior facial vein were harvested at 5 different time intervals (1, 2, 3, 6 and 12 months) post surgery and evaluated with light microscopy. A 100% long-term patency was noted both in arteries and veins. Quantitative measurements of the width of the vessel wall components indicated that a statistically significant temporary hypertrophic response occurred in the arterial intima, culminating in the third month when the width of the vessel wall at the anastomotic level almost doubled the normal. After that the width of the vessel wall again declined but it remained thicker than the adjacent vessel wall at one year post surgery. Among the venous anastomoses, however, the wall thickness at the anastomotic level remained thinner than the adjacent vessel wall throughout the evaluation period. The original vessel wall characteristics are not restored at the anastomotic site with intimal hyperplasia compensating for medial necrosis. Despite these events a technically satisfactory microvascular anastomosis should remain patent for years.
在术后5个不同时间间隔（1、2、3、6和12个月）从兔颈动脉和面后静脉获取40个动脉和41个静脉的端到端微血管缝合吻合口，并用光学显微镜进行评估。动脉和静脉均观察到100%的长期通畅率。对血管壁各成分宽度的定量测量表明，动脉内膜出现了具有统计学意义的暂时性肥厚反应，在第三个月达到顶峰，此时吻合口水平的血管壁宽度几乎比正常情况增加了一倍。此后血管壁宽度再次下降，但在术后一年仍比相邻血管壁厚。然而，在静脉吻合口中，在整个评估期间，吻合口水平的壁厚仍比相邻血管壁薄。吻合部位未恢复原始血管壁特征，内膜增生补偿了中层坏死。尽管发生了这些情况，技术上令人满意的微血管吻合术仍应保持数年通畅。
