Ranta R, Rintala A
Scand J Plast Reconstr Surg. 1984;18(2):233-5. doi: 10.3109/02844318409052843.
Separate clefts of the lip and of the palate (CL-CP) may belong to the same etiological class as the cleft lip with or without cleft palate CL(P), or a child may have two separate anomalies, CL and CP. This theory was tested in Finnish cleft patients. Among 2471 cleft cases, there were 66 CL-CP (2.7%). Adequate medical records were available for 62 children: 45 boys (73%) and 17 girls (27%). Familial occurrence was recorded in 6 cases (10%). Of the cleft cases among the near relatives, 5 were CL(P) and one CP. The prevalence of hypodontia was 37% among 38 subjects studied, as compared with 8.2% in the CL-, 29.8% in the CP- and 48.1% in the CLP controls. Conical elevations of the lower lip were observed in none, as compared with 0.8% of the CL(P)- and 39% of the CP controls. It was therefore assumed that the CL-CP belongs to the same etiological class as the CL(P).
唇腭裂（CL-CP）可能与伴有或不伴有腭裂的唇裂（CL(P)）属于同一病因类别，或者一个孩子可能有两种独立的异常情况，即唇裂（CL）和腭裂（CP）。该理论在芬兰腭裂患者中进行了验证。在2471例腭裂病例中，有66例唇腭裂（2.7%）。62名儿童有完整的病历：45名男孩（73%）和17名女孩（27%）。有6例（10%）记录有家族发病情况。在近亲中的腭裂病例中，5例为唇裂（CL(P)），1例为腭裂（CP）。在38名研究对象中，缺牙症的患病率为37%，而在唇裂（CL-）对照组中为8.2%，腭裂（CP-）对照组中为29.8%，唇腭裂（CLP）对照组中为48.1%。下唇未见锥形隆起，而在唇裂（CL(P)）对照组中为0.8%，腭裂对照组中为39%。因此，推测唇腭裂（CL-CP）与唇裂（CL(P)）属于同一病因类别。
