Higley H R, Rowden G
Thymus. 1984;6(4):243-53.
The lymphoid interdigitating cell (IDC) was investigated in human and rat thymus. A glial protein, S-100, was demonstrated in IDCs found in the human and rat thymic medulla by light microscopic immunocytochemistry. This marker served to distinguish IDCs from conventional macrophages of the thymic cortex. IDCs were S-100+, lysozyme-. Cortical macrophages were S-100-, lysozyme+. Thymic epithelial cells and lymphocytes possessed none of these markers. Examination of human fetal thymic tissue revealed that the IDC is present within the thymus very early in embryogenesis. Ultrastructural analysis of a developmental series of the rat thymus identified IDCs and macrophages. Medullary IDCs possessed many of the morphologic features of the epidermal Langerhans cell including the Birbeck granule. Cortical macrophages contained many inclusion bodies and lysosomes indicative of active phagocytosis. Some changes in IDC shape and structure were noted during maturation in the rat that may reflect the migration of this cell into the thymic parenchyma.
对人和大鼠胸腺中的淋巴样交错突细胞（IDC）进行了研究。通过光学显微镜免疫细胞化学方法，在人和大鼠胸腺髓质中的IDC中证实了一种神经胶质蛋白S - 100。该标志物用于将IDC与胸腺皮质中的传统巨噬细胞区分开来。IDC为S - 100阳性、溶菌酶阴性。皮质巨噬细胞为S - 100阴性、溶菌酶阳性。胸腺上皮细胞和淋巴细胞不具备这些标志物。对人胎儿胸腺组织的检查显示，IDC在胚胎发育早期就存在于胸腺内。对大鼠胸腺发育系列进行的超微结构分析鉴定出了IDC和巨噬细胞。髓质IDC具有表皮朗格汉斯细胞的许多形态学特征，包括伯贝克颗粒。皮质巨噬细胞含有许多包涵体和溶酶体，表明其具有活跃的吞噬作用。在大鼠成熟过程中，注意到IDC的形状和结构有一些变化，这可能反映了该细胞向胸腺实质的迁移。
