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肝脏三酰甘油合成与分泌的调节

Regulation of hepatic triacylglycerol synthesis and secretion.

作者信息

Haagsman H P, van Golde L M

出版信息

Vet Res Commun. 1984 Aug;8(3):157-71. doi: 10.1007/BF02214708.

DOI:10.1007/BF02214708
PMID:6495632
Abstract

Triacylglycerols are the most concentrated storage form of energy for the mammalian organism. These lipids are synthesized and secreted by the liver and serve as a fuel for other tissues. This paper presents a brief review of the regulation of hepatic triacylglycerol synthesis and secretion. Particular attention will be given to the dissociation of the synthesis of triacylglycerols from that of the metabolically closely related nitrogenous phospholipids. Recent evidence is presented which suggests that triacylglycerol synthesis (and secretion) is regulated, at least partially, at the diacylglycerol branchpoint.

摘要

三酰甘油是哺乳动物机体中能量最密集的储存形式。这些脂质由肝脏合成并分泌,作为其他组织的燃料。本文简要综述了肝脏三酰甘油合成与分泌的调节。将特别关注三酰甘油合成与代谢密切相关的含氮磷脂合成的解离。文中给出了近期证据,表明三酰甘油的合成(及分泌)至少部分地在二酰甘油分支点处受到调节。

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1
Regulation of hepatic triacylglycerol synthesis and secretion.肝脏三酰甘油合成与分泌的调节
Vet Res Commun. 1984 Aug;8(3):157-71. doi: 10.1007/BF02214708.
2
Secretion and storage of newly synthesized hepatic triacylglycerol fatty acids in vivo in different nutritional states and in diabetes.新合成的肝脏三酰甘油脂肪酸在不同营养状态及糖尿病状态下的体内分泌与储存。
Biochem J. 1988 Nov 1;255(3):929-35. doi: 10.1042/bj2550929.
3
Effect of nutritional state on the utilization of fatty acids for hepatitic triacylglycerol synthesis and secretion as very-low-density lipoprotein.营养状态对脂肪酸用于肝脏三酰甘油合成及作为极低密度脂蛋白分泌的利用情况的影响。
Biochem J. 1991 Apr 1;275 ( Pt 1)(Pt 1):87-92. doi: 10.1042/bj2750087.
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Cholesterol is required for the secretion of the very-low-density lipoprotein: in vivo studies.极低密度脂蛋白的分泌需要胆固醇:体内研究。
Biochim Biophys Acta. 1990 Jun 14;1044(3):297-304. doi: 10.1016/0005-2760(90)90073-7.
5
The effects of insulin and glucagon on the release of triacylglycerols by isolated rat hepatocytes are mere reflections of the hormonal effects on the rate of triacylglycerol synthesis.胰岛素和胰高血糖素对分离的大鼠肝细胞释放三酰甘油的影响,仅仅反映了激素对三酰甘油合成速率的影响。
Biochim Biophys Acta. 1981 Jul 24;665(1):1-7. doi: 10.1016/0005-2760(81)90224-1.
6
Hepatic fatty acid metabolism as a determinant of plasma and liver triacylglycerol levels. Studies on tetradecylthioacetic and tetradecylthiopropionic acids.肝脏脂肪酸代谢作为血浆和肝脏三酰甘油水平的决定因素。关于十四烷基硫代乙酸和十四烷基硫代丙酸的研究。
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Soybean phospholipid dependent reductions in triacylglycerol concentration and synthesis in the liver of fasted-refed rats.大豆磷脂对禁食-再喂养大鼠肝脏中三酰甘油浓度和合成的依赖性降低。
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Reciprocal responses to dietary diacylglycerol of hepatic enzymes of fatty acid synthesis and oxidation in the rat.大鼠肝脏脂肪酸合成与氧化酶对膳食二酰甘油的相互反应。
Br J Nutr. 1997 Jan;77(1):107-121. doi: 10.1079/bjn19970013.

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Int J Mol Sci. 2020 Nov 27;21(23):9021. doi: 10.3390/ijms21239021.
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Effects of dexamethasone and insulin on the synthesis of triacylglycerols and phosphatidylcholine and the secretion of very-low-density lipoproteins and lysophosphatidylcholine by monolayer cultures of rat hepatocytes.地塞米松和胰岛素对大鼠肝细胞单层培养物中三酰甘油和磷脂酰胆碱合成以及极低密度脂蛋白和溶血磷脂酰胆碱分泌的影响。
Biochem J. 1986 Jan 1;233(1):151-60. doi: 10.1042/bj2330151.
3

本文引用的文献

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INTRACELLULAR DISTRIBUTION OF SOME ENZYMES CATALYZING REACTIONS IN THE BIOSYNTHESIS OF COMPLEX LIPIDS.参与复合脂质生物合成中催化反应的某些酶的细胞内分布
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Distribution of glycerolipid-synthesizing enzymes in the subfractions of rat liver microsomes.大鼠肝脏微粒体亚组分中甘油脂质合成酶的分布
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Formation of the very low density lipoprotein and metabolism of [1-14C]-oleate by perfused livers from rats treated with triiodothyronine or propylthiouracil.
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地塞米松对培养的大鼠肝细胞极低密度脂蛋白和高密度脂蛋白中载脂蛋白分泌的刺激作用。
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Increased formation of triglyceride from oleate in perfused livers from pregnant rats.在怀孕大鼠的灌注肝脏中,油酸生成甘油三酯的过程增强。
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Sex steroid modulation of fatty acid utilization and fatty acid binding protein concentration in rat liver.性类固醇对大鼠肝脏脂肪酸利用及脂肪酸结合蛋白浓度的调节作用
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Triacylglycerol metabolism in the phenobarbital-treated rat.苯巴比妥处理的大鼠中的三酰甘油代谢
Biochem J. 1981 Apr 15;196(1):337-46. doi: 10.1042/bj1960337.
7
Effect of hyperthyroidism and hypothyroidism on lipid and carbohydrate metabolism of the perfused rat liver.甲状腺功能亢进和减退对灌注大鼠肝脏脂质及碳水化合物代谢的影响。
Biochem J. 1981 Apr 15;196(1):247-55. doi: 10.1042/bj1960247.
8
Synthesis and secretion of very low density lipoproteins by isolated rat hepatocytes in suspension: role of diacylglycerol acyltransferase.悬浮培养的大鼠离体肝细胞极低密度脂蛋白的合成与分泌:二酰甘油酰基转移酶的作用
Arch Biochem Biophys. 1981 May;208(2):395-402. doi: 10.1016/0003-9861(81)90524-5.
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Regulation of palmitate esterification/oxidation by glucagon in isolated hepatocytes: the role of alpha-glycerophosphate concentration.胰高血糖素对分离肝细胞中棕榈酸酯化/氧化的调节:α-甘油磷酸浓度的作用。
Biochim Biophys Acta. 1980 Dec 5;620(3):364-71. doi: 10.1016/0005-2760(80)90128-9.
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Precursor supply and hepatic enzyme activities as regulators of triacylglycerol synthesis in isolated hepatocytes and perfused liver.
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