Dilov P, Antonov S, Chakŭrov R, Petkov R, Gabrovski P
Vet Med Nauki. 1984;21(6):91-100.
Comparative studies were carried out with dextrofer-100 with B12 and dextrofer-100 in terms of acute toxicity (albino mice), absorption (rabbits, pigs, and lambs), deposition of iron in the liver and spleen (rabbits, pigs, and lambs) and antianemic action (pigs and lambs). It was found that LD50 of dextrofer-100 with B12 at i/v introduction into 18-20-gram albino mice was 1750 mg Fe3+/kg body mass; with regard to toxicity it was shown to correspond to the British Veterinary Code. The toxicity of dextrofer-100, studied by the same test, was practically undeterminable. By the level of sideremia dextrofer-100 with B12 did not differ essentially from dextrofer-100 and was said to belong to preparations with rapid absorption. It was most rapidly absorbed in pigs, rabbits and lambs following next. It supplied enough iron to the reticuloendothelial organs--in pigs it was (on a percent basis) highest in the liver, and in lambs--in the spleen. In pigs on the 10th day following treatment with dextrofer-100 with B12 the liver was shown to have vitamin B12 5 times as much. By its antianemic effect at i/m application to newborn pigs and lambs dextrofer-100 with B12 did not differ essentially from dextrofer-100 (its action was negligibly broader), however, it was beneficial to the growth of pigs.
对右旋糖酐铁 -100与维生素B12组合制剂以及右旋糖酐铁 -100进行了急性毒性（白化小鼠）、吸收（兔子、猪和羔羊）、肝脏和脾脏中铁的沉积（兔子、猪和羔羊）以及抗贫血作用（猪和羔羊）方面的比较研究。结果发现，将右旋糖酐铁 -100与维生素B12静脉注射给18 - 20克的白化小鼠时，其半数致死量为1750毫克Fe3+/千克体重；就毒性而言，它符合英国兽药规范。通过相同试验研究的右旋糖酐铁 -100的毒性实际上无法确定。从血清铁水平来看，右旋糖酐铁 -100与维生素B12组合制剂与右旋糖酐铁 -100基本没有差异，属于吸收迅速的制剂。它在猪体内吸收最快，其次是兔子和羔羊。它为网状内皮器官提供了足够的铁——在猪体内，肝脏中的铁含量（按百分比计算）最高，在羔羊体内，脾脏中的铁含量最高。在给猪用右旋糖酐铁 -100与维生素B12治疗后的第10天，肝脏中的维生素B12含量是原来的5倍。在对新生猪和羔羊肌肉注射时，右旋糖酐铁 -100与维生素B12的抗贫血作用与右旋糖酐铁 -100基本没有差异（其作用范围略有扩大），然而，它对猪的生长有益。
