Semiglazov V F, Gershanovich M L, Kondrat'ev V B, Moiseenko V M
Vopr Onkol. 1984;30(9):39-43.
The efficacy of tamoxifen treatment was studied in 46 postmenopausal patients with localized and disseminated breast cancer. Objective remissions were observed in 47.8, stabilization of tumor process-in 21.7%, mostly in cases of metastasis into the skin, subcutaneous fat, lymph nodes, pleura and bones. Tamoxifen proved sufficiently effective both in primary treatment and as a measure taken when the effect of a specific therapy (radiation, cytostatic or hormonal) was over. Side-effects were slight and were registered in 19.6%.
对46例绝经后局部和播散性乳腺癌患者的他莫昔芬治疗效果进行了研究。观察到客观缓解率为47.8%，肿瘤进展稳定率为21.7%，主要发生在皮肤、皮下脂肪、淋巴结、胸膜和骨转移的病例中。他莫昔芬在初始治疗以及特定治疗（放疗、细胞毒性药物或激素治疗）效果消失后采取的措施中均证明有足够疗效。副作用轻微，发生率为19.6%。
