Avrutskiĭ G Ia, Allikmets L Kh, Neduva A A, Zharkovskiĭ A M, Beliakov A V
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(8):1213-20.
Clinical and experimental studies into the phenomenon of adaptation to neuroleptic agents and into the methods of its overcoming were carried out. An experimental study of the long-term administrations of haloperidol revealed the formation of adaptation to the drug which can be overcome by a zigzag-like sharp elevation of the dosage followed by rapid reduction to the baseline level. The trial of this method under clinical conditions showed that it was expedient to use on a large scale the experimental findings on the specific features of the formation and prevention of the secondary therapeutic resistance.
开展了关于对神经安定药物适应现象及其克服方法的临床和实验研究。对氟哌啶醇长期给药的实验研究揭示了对该药物适应性的形成，这种适应性可通过剂量呈锯齿状急剧升高随后迅速降至基线水平来克服。在临床条件下对该方法的试验表明，大规模应用关于继发性治疗抵抗形成和预防的具体特征的实验结果是适宜的。
