Skottner A, Forsman A, Löfberg E, Thorngren K G
Acta Endocrinol (Copenh). 1984 Oct;107(2):192-8. doi: 10.1530/acta.0.1070192.
In hypophysectomized male rats the biological effects of two batches of methionyl human growth hormone, Somatonorm, (met-hGH), have been compared to those of human pituitary growth hormone, Crescormon (hGH). The rats were treated with doses ranging from 10 mIU per day to 145 mIU per day for 10 days. The parameters studied were total weight gain, longitudinal bone growth, measured by the tetracycline method and indirect cartilage growth, measured by uptake of radioactive sulphate. The results obtained demonstrated that Somatonorm stimulated weight increase in a linear and dose-dependent way, similar to that seen with the native hormone. Longitudinal bone growth, measured by the tetracycline method and the growth of different cartilages, measured as uptake of radioactive sulphate, were also similar between the two hormones.
在垂体切除的雄性大鼠中，已将两批甲硫氨酰人生长激素（生长激素索马诺明，met-hGH）的生物学效应与人生长激素（克瑞司可蒙，hGH）的生物学效应进行了比较。给大鼠每日注射10 mIU至145 mIU的剂量，持续10天。所研究的参数包括总体重增加、通过四环素法测量的纵向骨生长以及通过放射性硫酸盐摄取测量的间接软骨生长。获得的结果表明，生长激素索马诺明以线性且剂量依赖性的方式刺激体重增加，类似于天然激素的情况。通过四环素法测量的纵向骨生长以及作为放射性硫酸盐摄取测量的不同软骨的生长，在两种激素之间也相似。
