Sindberg Eriksen P, Gennser G, Lindvall R, Nilsson K
Acta Obstet Gynecol Scand. 1984;63(5):385-90. doi: 10.3109/00016348409156689.
The purpose of this study was to analyse the acute effects of maternal cigarette smoking on the fetal heart beat intervals and their variability during the last trimester of a normal gestation. The fetal heart beat intervals were monitored continuously by abdominal electrocardiography for 60 min before and 60 min after smoking in 10 pregnant women. The mean intervals, their long-term variability (SD) and short-term variability (standard deviation of interval differences (SDID], calculated for 30-sec periods, showed a steady state before smoking. During the control period, the mean beat interval was negatively correlated with daily cigarette consumption and the short-term variability was positively correlated with the maternal plasma nicotine level. After smoking, the mean beat interval and the short-term variability decreased transiently, the values of both these parameters being positively correlated with the maternal nicotine values before smoking. The acute response of fetal heart beat intervals and their variability to one cigarette is distinct but transient, and the results suggest that the effects are modified by the chronic smoking habits of the women.
本研究的目的是分析孕期最后三个月母亲吸烟对胎儿心跳间期及其变异性的急性影响。通过腹部心电图对10名孕妇吸烟前60分钟和吸烟后60分钟的胎儿心跳间期进行连续监测。平均间期、其长期变异性（标准差）和短期变异性（间期差异标准差[SDID]，按30秒时段计算）在吸烟前呈稳定状态。在对照期，平均心跳间期与每日吸烟量呈负相关，短期变异性与母亲血浆尼古丁水平呈正相关。吸烟后，平均心跳间期和短期变异性短暂下降，这两个参数的值与吸烟前母亲的尼古丁值呈正相关。胎儿心跳间期及其变异性对一支香烟的急性反应是明显但短暂的，结果表明这些影响会因女性的长期吸烟习惯而改变。
