Hedman S E, Andersson R G
Acta Pharmacol Toxicol (Copenh). 1984 Aug;55(2):116-20. doi: 10.1111/j.1600-0773.1984.tb01972.x.
Isolated sensitized guinea pig tracheal smooth muscle tone was induced by use of egg albumin or SRS-A (slow reacting substance of anaphylaxis). The dose-response relationships of theophylline and enprofylline were studied on these preparations. Enprofylline was more potent than theophylline in relaxing the egg albumin- or SRS-A-induced tracheal muscle tone. The theophylline relaxation-curve was significantly shifted to the left after addition of adenosine-deaminase to the egg albumin-contracted trachea, but this was not observed with the enprofylline relaxation-curve. In SRS-A-contracted tracheas, the addition of adenosine-deaminase did not significantly alter the relaxation curves of theophylline or enprofylline. It is therefore suggested that the relaxing effects of theophylline and enprofylline on SRS-A-induced contractions, at the therapeutically relevant concentrations demonstrated in this study, might be of importance for the anti-asthmatic effects of xanthines.
使用卵清蛋白或SRS-A（过敏反应慢反应物质）诱导豚鼠气管平滑肌产生孤立的致敏张力。研究了茶碱和恩丙茶碱在这些制剂上的剂量-反应关系。在松弛由卵清蛋白或SRS-A诱导的气管肌张力方面，恩丙茶碱比茶碱更有效。在卵清蛋白收缩的气管中加入腺苷脱氨酶后，茶碱的松弛曲线显著左移，但恩丙茶碱的松弛曲线未观察到这种情况。在SRS-A收缩的气管中，加入腺苷脱氨酶并未显著改变茶碱或恩丙茶碱的松弛曲线。因此，提示在本研究中所显示的治疗相关浓度下，茶碱和恩丙茶碱对SRS-A诱导的收缩的松弛作用，可能对黄嘌呤类药物的抗哮喘作用具有重要意义。
